ABSTRACT
Objective To investigate the early sensitive signs of the micro meningioma using CT and MRI and to improve the detection rate. Methods A retrospective analysis of the clinical and imaging data of 41 patients with micro meningioma was conducted,who were diagnosed by clinical following-up and pathological results.The position and the features of CT and MRI of the intracranial meningiomas were calculated and analyzed.Results Of the 21 patients with micro meningioma who underwent CT scan,5 cases presented calcification density,12 cases showed high or slightly high density,4 cases showed isodensity.All participants were underwent MRI.Among of them,37 cases with isointensity and 4 cases with hypointensity on T1 WI;On T2 WI,33 cases with isointensity,4 cases with hyperintensity and 4 cases with hypointensity;and 14 cases with slight hyperintensity,27 cases with isointensity on FLAIR.Of the 13 micro meningioma who did DWI,5 cases with hyperintensity or slight hyperintensity.All lesions were obviously enhanced.Conclusion Multimodal MRI (FLAIR,DWI ),enhanced scan and thin slice from different directions (sagittal plane),combined with CT may greatly reduce the omission diagnostic rate.
ABSTRACT
Objective To investigate the early sensitive signs of the micro meningioma using CT and MRI and to improve the detection rate. Methods A retrospective analysis of the clinical and imaging data of 41 patients with micro meningioma was conducted,who were diagnosed by clinical following-up and pathological results.The position and the features of CT and MRI of the intracranial meningiomas were calculated and analyzed.Results Of the 21 patients with micro meningioma who underwent CT scan,5 cases presented calcification density,12 cases showed high or slightly high density,4 cases showed isodensity.All participants were underwent MRI.Among of them,37 cases with isointensity and 4 cases with hypointensity on T1 WI;On T2 WI,33 cases with isointensity,4 cases with hyperintensity and 4 cases with hypointensity;and 14 cases with slight hyperintensity,27 cases with isointensity on FLAIR.Of the 13 micro meningioma who did DWI,5 cases with hyperintensity or slight hyperintensity.All lesions were obviously enhanced.Conclusion Multimodal MRI (FLAIR,DWI ),enhanced scan and thin slice from different directions (sagittal plane),combined with CT may greatly reduce the omission diagnostic rate.
ABSTRACT
Objective To investigate the significance of galactose galectin-3(Galectin-3)and matrix metalloproteinase-2(MMP-2)expression in gliomas patients and thire role in process of gliomas' malignancy development. Methods Immunohistochemistry was used to detect Galectin-3 and MMP-2 protein expression in 5 normal brain tissue and 40 patients with different grade gliomas. According to positive cells number of Galectin-3,MMP-2 in tumor cells under a microscope,to determine the expression,and the positive index(LI)which came from the percentage of the positive cell number out of the total cell number was to expressed the number of positive cell. Results Galectin-3 and MMP-2 protein expression in normal brain tissue were negative. In glioma tissues,Galectin-3 was mainly expressed in the cytoplasm and membrane of tumor cells. In 23 glioma tissue withⅠor Ⅱ grade,9 cases(39. 13% )was positive and the LI values was(5. 65 ± 3. 47)% in terms of Galectin-3 expression. In Ⅲ,Ⅳ grade glioma specimens,the positive rate of Galectin-3 expression was 76. 47%(13 / 17), and LI value was(27. 88 ± 22. 13)% . The difference of Galectin-3 expression and LI value were significant between specimens with Ⅰ,Ⅱ grade and Ⅲ,Ⅳ significant( χ2 = 4. 101,t = 4. 105;P < 0. 05). In human gliomas,MMP-2 expression protein was mainly expressed in tumor cells and vascular basement membrane of the endothelial cell cytoplasm. In 23 glioma tissue with Ⅰor Ⅱ grade,9 cases(39. 13% )was positive and the LI values was(5. 91 ± 4. 78)% in terms of MMP-2 expression. In Ⅲ,Ⅳ grade glioma specimens,the positive rate of MMP-2 expression was 88. 24%(15 / 17),and LI value was(30. 06 ± 22. 94)% . The difference of MMP-2 expression was significant between specimens with Ⅰ,Ⅱ grade or Ⅲ,Ⅳ grade( χ2 = 7. 882,t = 4. 271;P< 0. 05). The linear correlation analysis showed that there was positively correlation between Galectin-3 and MMP-2 positive cells(r = 0. 800,P < 0. 05). Conclusion Galectin-3 and MMP-2 protein expression in Ⅰ,Ⅱgrade gliomas is significantly lower than those inⅢ,Ⅳ grade glioma,and they are positively related with the progress of malignant gliomas. Galectin-3 and MMP-2 protein can be used to evaluate or judge the malignant stage of human brain glioma.